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Phiazolidinedione antidiabetics such as pioglitazone may cause or worsen heart failure in some patients. Tell your doctor if you have a history of heart failure. Pioglitazone should not be used to treat patients with moderate to severe heart failure. You will be monitored for signs of heart failure when you start pioglitazone and when your dose increases. Contact your doctor at once if you develop swelling of the hands, ankles, or feet; shortness of breath; or sudden, unexplained weight gain. Your doctor may need to stop your medicine or change your dose.
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